Exploring the Impact of GLP-1 Therapy on Muscle and Bone Health

By: Leigh Ann Mansell, RN, CPSN

5/13/2025

GLP-1's drop weight, but at what cost? Muscle and bone loss can hit harder for those in the peri stage of life. GLP-1 is a hormone that helps regulate blood sugar levels and can lead to weight loss. While this may seem like a positive outcome for many individuals struggling with obesity, it is important to consider the potential impact on muscle and bone health. 

As we age, our muscle mass naturally decreases, which can lead to a higher risk of falls and fractures. When coupled with weight loss from GLP-1, this risk can be even greater. Additionally, muscle loss can also slow down metabolism, making it harder to maintain weight loss in the long term. 

Bone health is also a concern when it comes to GLP-1 and weight loss. Bone density can decrease with age, and weight loss can further accelerate this process. This can increase the risk of osteoporosis and fractures, especially in postmenopausal women. 

It is important for individuals considering GLP-1 therapy for weight loss to discuss the potential risks with their healthcare provider. It may be necessary to incorporate strategies to preserve muscle and bone health, such as strength training and adequate calcium intake. 

While weight loss can have many benefits for overall health, it is essential to consider the potential impact on muscle and bone health, particularly for those in the peri stage of life. Finding a balance between weight loss and preserving muscle and bone health is key to achieving long-term success.

* All information subject to change. Images may contain models. Individual results are not guaranteed and may vary.